Application of intra-arterial infusion chemotherapy in concurrent chemoradiation therapy of local advanced cervical cancer
10.3969/j.issn.1002-1671.2016.02.026
- VernacularTitle:动脉内灌注化疗在局部晚期宫颈癌同步放化疗中的应用
- Author:
Dingquan WU
;
Hengwu CUI
;
Jianchun YAN
;
Jian CHEN
- Publication Type:Journal Article
- Keywords:
cervical cancer;
intra-arterial;
chemotherapy;
concurrent chemoradiation therapy
- From:
Journal of Practical Radiology
2016;(2):266-269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feasibility and clinical efficacy of intra-arterial infusion chemotherapy within concurrent chemoradiation therapy (CCRT)for local advanced cervical cancer (LACC:Stage Ⅰb2 - Ⅳa).Methods 42 LACC patients were treated with CCRT combining with intra-arterial infusion chemotherapy (CCRT group),and another 60 LACC patients were under-went radiotherapy alone (control group).The clinical efficacy,adverse reactions and overall survivals (OAS)were evaluated,be-tween the two groups,respectively.Results Overall response rate was 92.8% in CCRT group.Of 42 patients,24 had achieved complete response (CR)in CCRT group (57.1%).The 5-year overall survival rate in CCRT group was 76.2%,which was signifi-cantly higher than that of control group (49.3%),respectively (P =0.01).Multivariate COX proportional hazards model revealed that the clinical stage(P =0.01 6),pelvic positive lymph nodes (P =0.007)were independent factors of monitoring prognosis of LACC patients treated with CCRT combining with intra-arterial infusion chemotherapy.Conclusion CCRT with intra-arterial infu-sion chemotherapy is a safe and effective method for LCCA,and clinical stage and pelvic positive lymph node were independent fac-tors of the prognosis of patients.
