A clinical study of Danhong injection combined with calcium dobesilate for diabetic ;retinopathy
10.3760/cma.j.issn.1673-4246.2016.02.009
- VernacularTitle:丹红注射液配合羟苯磺酸钙治疗糖尿病视网膜病变临床研究
- Author:
Wenli YU
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Visual acuity;
Visual fields;
Calcium dobesilate;
Danhong injection
- From:
International Journal of Traditional Chinese Medicine
2016;(2):128-131
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effect of Danhong injection combined with calcium dobesilate for diabetic retinopathy (DR). Methods A total of 81 DR patients were recruited and randomly divided into a calcium dobesilate group (41 patients) and a combined treatment group (40 patients). Blood glucose was controlled (fasting blood sugar 4.5-6.5 mmol/L, postprandial 2 h blood glucose ≤10.0 mmol/L) in all patients. The calcium dobesilate group received oral calcium dobesilate tablets (0.5 g, 3/day), and the combined treatment group received intravenous Danhong Injection and oral calcium dobesilate tablets (0.5 g, 3/day) for 3 months. The changes of the gray scale of the visual field, microaneurysm volume, ecchymosis area, the thickness of the macula lutea, and the therapeutic effect were evaluated. Results After the treatment, the gray scale of the visual field (1.53%± 0.22%vs. 2.13%± 0.16%;t=17.315, P<0.01), microaneurysm volume (11.33 ± 3.21 cm3 vs. 13.44 ± 4.01 cm3; t=3.259, P<0.01), ecchymosis area (1.11 ± 0.24 mm2 vs. 2.01 ± 0.53 mm2; t=9.885, P<0.01), the thickness of the macula lutea (308.12 ± 13.29?m vs. 369.31 ± 14.57?m;t=24.556, P<0.01). The percentage of eyes with visual acuity improvement was in the combined treatment group was significantly higher than that in the calcium dobesilate group (63.1%vs. 35.0%;χ2=8.748, P=0.003). The total effective rates in the combined treatment group were significantly higher than those in the calcium dobesilate group for patients (95.1%vs. 67.5%;χ2=8.489, P=0.004) and for eyes (93.8%vs. 61.7%;χ2=17.226, P=0.001). Conclusions Danhong injection combined with calcium dobesilate can improve visual acuity and visual field loss in patients with DR.
