Value of infection indicators in early diagnosis of hand,foot and mouth disease with bacterial infection
10.3969/j.issn.1006-5725.2016.06.042
- VernacularTitle:感染指标在手足口病早期合并细菌感染的诊断价值
- Author:
Xue HAN
;
Jiang CHENG
;
Weize ZUO
;
Yajing MA
- Publication Type:Journal Article
- Keywords:
Hand;
foot and mouth disease;
Bacterial infections;
Cytokines;
procalcitonin;
C-reactive protein
- From:
The Journal of Practical Medicine
2016;32(6):996-998
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore serum IL-6 (interleukin-6) ,IL-10 (interleukin-10), the WBC (white blood cell count), CRP (C-reactive protein)and PCT ( procalcitonin ) level in early diagnosing of in children with hand, foot and mouth disease and bacterial infection. Methods 63 children in bacterial infection group and virus infection group respectively,collected 63 children in normal control group by physical examination. Enzyme-linked immunosorbent assay (ELISA) double antibody clamp method was used to determine serum IL-6 and IL-10 level. Immune turbidimetric , enzyme-linked fluorescent were used to detected serum CRP , PCT. WBC results were also compared. Resluts Serum IL-6, IL-10, CRP and PCT level were higher in normal control group compared with virus infection group , the WBC level was slightly lower than normal control grou with statistically different IL-6, IL-10, CRP level (P < 0.05);serum IL-6, IL-10, WBC, CRP and PCT levels in Bacteria infection group were higher than virus infection group and normal control group , while their serum WBC, CRP and PCT level were statistically significant compared to virus infection group (P < 0.05),IL-6 and IL-10 were no statistical different (P > 0.05). Conclusion IL-6, IL-10 levels increased significantly in the early stage of hand,foot and mouth disease, but in the aspect of combination of bacterial infection and bacterial infection, their clinical value was not so significant. WBC, CRP and PCT level had important value for early diagnosis in hand, foot and mouth disease with bacterial infection.
