Correlation between MRI features and HER-2 expression in non-mass-like breast carcinoma
10.3969/j.issn.1002-1671.2016.02.013
- VernacularTitle:非肿块型乳腺癌的 MRI 表现与 HER-2表达的相关性研究
- Author:
Maolin XU
;
Danke SU
;
Dong XIE
;
Guanqiao JIN
;
Shaolü LAI
;
Fang LI
;
Zheng WANG
;
Ningbin LUO
;
Wei KANG
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
non-mass-like breast carcinoma;
magnetic resonance imaging;
HER-2
- From:
Journal of Practical Radiology
2016;(2):216-219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of MRI features with HER-2 expression in non-mass-like breast carcinoma. Methods 74 patients with breast cancers diagnosed by pathology underwent MRI prior to surgery,and all lesions were non-mass-like enhancement on dynamic contrast-enhanced MRI.The expression of HER-2 in tumor tissue was detected by immunohistochemical staining.Chi-square test,Fisher’s exact test and spearman rank correlation were used to evaluate the correlations between the morphological characteristics, dynamic enhanced MR parameters,ADC value and HER-2 expression.Results The tumor size was correlated positively with the expression degree of HER-2 (r=0.341,P =0.003).The ADC value was also correlated positively with the positive expression degree of HER-2 (r=0.31 7,P =0.006).However,the time to peak was correlated negatively with that (r =-0.244,P =0.036).No significant correlations between the distribution/internal enhancement manner,the type of time signal intensity curve and HER-2 expression were found (all P >0.05).Conclusion Tumor size,time to peak and ADC value are correlated with the expression of HER-2 in non-mass-like breast carcinoma,which is helpful for the treatment plan and prognosis evaluation for this cancer.
