Correlation analysis between KCNJ11 polymorphism and essential hypertension in Kazakh from Xinjiang
10.3969/j.issn.1006-5725.2016.06.008
- VernacularTitle:新疆哈萨克族原发性高血压与KCNJ11基因多态性的相关分析
- Author:
Lijie WANG
;
Wenwen ZHANG
;
Liang ZHANG
;
Lei ZHAO
;
Ketao MA
;
Li LI
;
Junqiang SI
- Publication Type:Journal Article
- Keywords:
Essential hypertension;
Kazak;
Gene polymorphism
- From:
The Journal of Practical Medicine
2016;32(6):894-896
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between KCNJ11-E23K polymorphism and essential hypertension (EH) in Kazakh from Xinjiang. Methods PCR-RFLP method was used to test KCNJ11-E23K genotypes of Kazakh from Xinjiang,including 237 EH patients and 221 normotension (NT). Logistic regression analysis was used to analyze the risk factors associated with EH. Results The frequencies of KCNJ11-E23K genotype (EE and (EK + KK)) and allele (E and K) were 34.18%, 65.82%, 61.60% and 38.40%respectively in EH group. There was a significant difference between two groups (P < 0.05). Weight and EE genotype were risk factors affecting EH in Kazakh from Xinjiang. Individual who carried EE genotype and allele E were 2.501 and 1.388 times than (EK + KK) and allele K suffered from EH respectively. Conclusion KCNJ11-E23K polymorphism was associated with EH in Kazakh from Xinjiang.
