Relationship between Hcy and CBS-T833C gene polymorphism and breast cancer in Han of Xinjiang Population
10.3969/j.issn.1006-5725.2016.06.009
- VernacularTitle:Hcy及CBS T833C基因多态性与新疆汉族乳腺癌的关系
- Author:
Wei ZHANG
;
Zhigang LI
;
Lei ZHANG
;
Lei ZHAO
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Gene;
CBS
- From:
The Journal of Practical Medicine
2016;32(6):897-899
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between T833C gene polymorphism of cystathionine-βsynthase (CBS) and breast cancer in Xinjiang Han nationality. Methods CBS-T833C gene polymorphism of 200 breast cancer patients in Xinjiang Han nationality (breast cancer group) and 200 health examination people (control group) was analyzed by amplification refractory mutation system (ARMS) assay, Hcy levels and biochemical parameters were detected by automatic biochemical analyzer , the correlation between CBS-T833C gene polymorphism and breast cancer in Xinjiang Han nationality was analyzed. Results 1. Genotype TT,TC,CC of CBS T833C gene in the breast cancer group and the control group were respectively 55.5%, 32.0%, 12.5%and 53.0%, 34.0%, 12.0%. The G, A allele frequency of CBS T833C gen in the two groups were 71.5%,28.5%and 70.0%, 29.0%,the overall frequency distribution between the two groups was not statistically different among the three genotypes (P > 0.05). 2. Hcy levels in plasma of TC, CC genotype were higher than TT genotype in breast cancer group (P <0.05). Conclusion Increase of homocysteine levels may correlates with breast cancer in Xinjiang Han nationality, CBS-T833C gene polymorphism has no correlation with breast cancer in Xinjiang Han nationality.
