Correlation between the levels of serum Klotho with renal impairment in chronic kidney disease patients
10.3969/j.issn.1006-5725.2016.06.015
- VernacularTitle:慢性肾脏病患者血清Klotho水平与肾功能损害的相关性
- Author:
Qifeng LIU
;
Jianming YE
;
Lixia YU
;
Jianhua FENG
;
Aolin HE
;
Shasha LI
- Publication Type:Journal Article
- Keywords:
Chronic kidney disease;
Klotho;
Renal impairment
- From:
The Journal of Practical Medicine
2016;32(6):916-919
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the level of serum Klotho with renal impairment in chronic kidney disease (CKD) patients. Methods 100 patients with CKD 1-5 stages (CKD group) and 30 non-CKD patients (control group) were enrolled. The serum of Klotho was detected by ELISA (enzyme-linked immunosorbent assay ) to investigate the correlation between the level of serum Klotho to progression of CKD. Results The levels of serum Klotho in CKD group 9.81 (7.45,12.2) ng/mL and control group 2.97 (1.75,5.23) ng/mL were significantly different (P < 0.01); The Klotho level declined as renal insufficiency progressed. Pearson correlation analysis showed that serum Klotho in CKD patients was positively correlated with eGFR (estimated glomerular filtration rate), blood calcium and hemoglobin,while was negatively correlated with phosphate, age, logserum creatinine, and logFGF-23. Multiple regression analysis showed age, logScr and logFGF-23 were independent factors for expression of serum Klotho in CKD patients. Conclusion Serum Klotho level in CKD patients decreased with the deterioration in renal function and serum Klotho maybe one of indicators to predict the progression of renal function in CKD patients.
