Alveolar bone defect repair using autologous bone marrow mesenchymal stem cells combined with platelet-rich fibrin
10.3969/j.issn.2095-4344.2016.01.001
- VernacularTitle:自体骨髓间充质干细胞复合富血小板纤维蛋白促进拔牙窝骨愈合
- Author:
Shuhui LI
;
Xiaowei DAI
;
Wenli ZHANG
;
Cheng CHEN
;
Peiling WU
- Publication Type:Journal Article
- Keywords:
Mesenchymal Stem Cels;
Fibrin;
Platelets;
Tissue Engineering
- From:
Chinese Journal of Tissue Engineering Research
2016;20(1):3-7
- CountryChina
- Language:Chinese
-
Abstract:
Abstract BACKGROUND: Alveolar bone deficiency wil not meet aesthetic and functional requirements for dental implants. OBJECTIVE:To observe the repair effect of passage 3 autologous bone marrow mesenchymal stem cels (BMSCs) and platelet-rich fibrin (PRF) on alveolar bone defects in rabbits. METHODS:Twenty-seven New Zealand rabbits were randomly divided into BMSCs/PRF group, PRF group and model group (n=9 per group). The left mandible incisors were extracted in al the rabbits under general anesthesia. BMSCs/PRF group was immediately implanted BMSCs/PRF composite into the alveolar socket, PRF group only implanted PRF, and model group implanted nothing. RESULTS AND CONCLUSION: In the model group, the alveolar crest and alveolar mucosa become sunken notably and narrowed. In the BMSCs/PRF and PRF groups, the thickness of alveolar bone wal, alveolar bone width, alveolar bone height difference, and bone mineral density were al increased, especialy in the former group. In addition, the trabecular arrangement was better in the BMSCs/PRF groups than the model and PRF group. Our findings indicate that alveolar socket filing with composite of BMSCs and PRF can achieve preservation of alveolar bone width and height after tooth extraction in rabbits.
