Neural stem cell transplantation for sequela of traumatic brain injury：the best timing for treatment
10.3969/j.issn.2095-4344.2016.10.015
- VernacularTitle:神经干细胞移植治疗颅脑损伤后遗症：最佳时机选择
- Author:
Yongli LOU
;
Ping CHEN
;
Yu JIANG
;
Hui ZHANG
;
Youhui MIN
- Publication Type:Journal Article
- Keywords:
Craniocerebral Trauma;
Neural Stem Cels;
Treatment Outcome;
Tissue Engineering
- From:
Chinese Journal of Tissue Engineering Research
2016;20(10):1474-1480
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Neural stem cel transplantation provides an important way to treat sequela of traumatic brain injury, but the timing for treatment is inconclusive.
OBJECTIVE:To explore the clinical effect of neural stem cel transplantation in the treatment of sequela of traumatic brain injury and the choice of the best treatment time.
METHODS: Totaly 178 patients with sequela of traumatic brain injury who underwent neural stem cel transplantation were divided into three groups as per the timing for neural stem cel transplantation: group A (with 6 months after injury,n=60), group B (6-12 months after injury,n=59), and group C (over 12 months after injury,n=59). Improvement in clinical symptoms and scores on function independent measure (FIM) were recorded and compared in the three groups.
RESULTS AND CONCLUSION:The total effective rate of group A was significantly higher than that in groups B and C (P < 0.05). FIM scores were significantly improved in the three groups after cel transplantation (P < 0.05). At 3 months after the fourth transplantation, the FIM score in the group A was significantly higher than that in the other two groups, and the incidence of adverse reactions in the group A was significantly lower than that in the other two groups (P < 0.05). These findings indicate that neural stem cel transplantation at different timing can al harvest certain clinical effects, but the best timing for neural stem cel transplantation is within 6 months after injury.
