Mechanisms of tumor invasion metastasis caused by long-term anti-angiogenic therapy
10.3969/j.issn.1000-8179.2016.07.150
- VernacularTitle:抗血管生成药物长期治疗致肿瘤侵袭转移相关机制的研究进展
- Author:
Jingjiao TANG
;
Xiaodong JIANG
- Publication Type:Journal Article
- Keywords:
anti-angiogenic therapy;
hypoxia inducible factors;
invasion;
metastasis;
epithelial-mesenchymal transition
- From:
Chinese Journal of Clinical Oncology
2016;43(7):310-313
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia results from long-term anti-angiogenic therapy and can stimulate hypoxia-inducible factors (HIFs). HIF-induced hy-poxia signaling is involved in various steps in tumor invasive-metastatic cascade. On the one hand, HIFs regulate epithelial-mesenchy-mal transition. On the other hand, the characteristics of pericytes around vessels and the links among endothelial cells can change;thus, tumor cells can more easily intravasate into blood vessels, survive in peripheral blood, and then reach specific organs, ultimately resulting in metastasis. This review discusses the emerging mechanisms of long-term anti-angiogenic therapy and the occurrence of metastasis.
