Detection of serum folate,homocysteine and vitamin B12 in patients with non-small cell lung cancer and its clinical significance
10.13481/j.1671-587x.20150626
- VernacularTitle:非小细胞肺癌患者血清叶酸、同型半胱氨酸和维生素 B12的检测及其临床意义
- Author:
Xiuyan YU
;
Wenlong WANG
;
Xuefeng WU
;
Xiaofeng LIU
- Publication Type:Journal Article
- Keywords:
non-small cell lung cancer;
folate;
homocysteine;
vitamin B12
- From:
Journal of Jilin University(Medicine Edition)
2015;(6):1235-1238
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the serum levels of folate,homocysteine (Hcy)and vitamin B12 in the patients with non-small cell lung cancer (NSCLC),and to clarify the clinical significance of folate, Hcy and vitamin B12 in the diagnosis and prognosis assessment of NSCLC.Methods 35 patients with NSCLC were chosen as NSCLC group, and 30 healthy people were selected as control group,excluding hypertension,anemia,family disease history and other related factors.The expression levels of serum folate, Hcy and vitamin B12 were examined by circulating enzymatic method and electrochemical luminescence method.The correlations between the levels of serum folate, Hcy and vitamin B12 of the objects in two groups were analyzed by Pearson test.Results The serum Hcy level of the patients in NSCLC group was significantly higher than that in control group (P <0.01).The serum folate level of the patients in NSCLC group was significantly lower than that in control group (P <0.01),while there was no significant difference in vitamin B12 levels between two groups (P > 0.05).The serum Hcy level was negatively correlated with folate level (r=-0.505,P =0.002),but was not correlated with vitamin B12 (r =-0.084,P =0.633).The serum folate level was not correlated with vitamin B12 (r=-0.039,P =0.826).Conclusion The serum Hcy level of NSCLC patient is significantly increased and it has diagnostic and prognostic values in the NSCLC patients.
