Severe Resistant Hypertension Induced by Carbamazepine in an Elderly Patient.
10.4235/jkgs.2013.17.2.99
- Author:
Seon Jae KIM
1
;
Jung A KOH
;
Hak Chul LEE
;
Si Eun KIM
;
Seong Taek CHU
;
Seung Hun LEE
;
Jung Ju SIR
;
Seung Min CHOI
;
Shin Bae JOO
;
Hong Soon LEE
;
Dae Hee HAN
Author Information
1. Department of Internal Medicine, National Medical Center, Seoul, Korea. seo0515@medimail.co.kr
- Publication Type:Case Report
- Keywords:
Carbamazepine;
Hypertension;
Tricyclic antidepressants
- MeSH:
Aged;
Antidepressive Agents, Tricyclic;
Blood Pressure;
Carbamazepine;
Humans;
Hyperaldosteronism;
Hypertension;
Pheochromocytoma;
Quaternary Ammonium Compounds;
Renal Artery Obstruction;
Syringomyelia
- From:Journal of the Korean Geriatrics Society
2013;17(2):99-102
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of a 73-year-old patient with a 17 year-history of well-controlled primary hypertension with a single antihypertensive drug, which became uncontrolled since 9 months ago when he started on oral carbamazepine (CBZ) therapy for syringomyelia. On admission, the patient had a blood pressure of 200-215/95-104mmHg despite an antihypertensive combination therapy with five different drugs. Further investigations ruled out secondary hypertension such as primary aldosteronism, pheochromocytoma and renal artery stenosis. After the discontinuation of CBZ, the blood pressure profile became significantly improved. The rechallenge with CBZ aggravated his blood pressure profile. Therefore, we considered that resistant hypertension was induced by the oral CBZ therapy.
