Influence of icaritin in proliferation and apoptosis of NB4 leukemia cells and its mechanism
10.13481/j.1671-587x.20150616
- VernacularTitle:淫羊藿苷对 NB4白血病细胞株增殖和凋亡的影响及其作用机制
- Author:
Fei SONG
;
Sujun GAO
;
Yunwei ZHANG
;
Yazhe DU
;
Lu WANG
;
Ruifang WANG
;
Long SU
- Publication Type:Journal Article
- Keywords:
Icaritin;
leukemia;
NB4 cells;
apoptosis
- From:
Journal of Jilin University(Medicine Edition)
2015;(6):1181-1185
- CountryChina
- Language:Chinese
-
Abstract:
of NB4 cells at S phase was lower than those in control group (P <0.05),and the number of NB4 cells at G1 phase was increased (P <0.05).The expression levels of Bcl-2 in ICA groups were significantly lower than that in control group (P < 0.05 ), while the expression levels of Bax were higher than that in control group (P < 0.05 ). Conclusion ICA can induce the apoptosis of NB4 cells via inhibiting the expression level of Bcl-2 and up-regulating the expression level of Bax.
