Effect of Duanteng Yimu Decoction on Bone Metabolism Markers of Adjuvant- induced Arthritis Rats
10.13359/j.cnki.gzxbtcm.2015.06.013
- VernacularTitle:断藤益母汤对佐剂性关节炎大鼠骨代谢标志物的影响
- Author:
Xujie LEI
;
Mingying ZHANG
;
Li GUO
;
Changsong LIN
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis/TCD therapy;
Duanteng Yimu Decoction/pharmacology;
Caulis Celastri/pharmacology;
Bone metabolism markers;
Disease models,animal;
Rats
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2015;32(6):1027-1030
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Duanteng Yimu decoction (DYD) on bone turnover markers of C-terminal telopeptide of type Ⅰ collagen (CTX-Ⅰ) and N-terminal propeptide of type Ⅰ procollagen ( PⅠNP) of adjuvant-induced arthritis (AA) rats. Methods Seventy-two SD rats were divided into 9 groups, and complete Freund's adjuvant was injected into the rats to establish adjuvant-induced arthritis rat model. After medication for 36 days, the pedal swelling, the serum levels of CTX-Ⅰand PⅠNP, and ankle X-ray photographic scores were observed. Results The pedal swelling degrees and ankle X-ray scores in medication groups were lower than those in the model group ( P<0.05). The PⅠNP level had no statistically significance in various groups ( P>0.05). The CTX-Ⅰlevel in low-dose DYD group was decreased (P<0.05). Conclusion Caulis Celastri has two-way effects on CTX-Ⅰlevel of female AA rats, and its side effects can be reduced by Radix Dipsaci and Herba Leonuri, but their antagonism effect will disappear with the increase of the dose of Caulis Celastri.
