Study on Dissolution and Degradation Characteristics of Phenolic Acids in Water Extract of Danshen Decoction
10.13359/j.cnki.gzxbtcm.2015.03.024
- VernacularTitle:丹参饮水提液酚酸类成分溶出特性及降解动力学研究
- Author:
Fangmin LIU
;
Hui LIN
;
Deyue WU
;
Zhenhua WANG
;
Daliang XU
;
Fei XIAO
;
Diling CHEN
;
Shuohui WANG
- Publication Type:Journal Article
- Keywords:
Danshen Decoction/chemistry;
Tanshinol/analysis;
Protocatechuic aldehyde/analysis;
Salvianolic acid B/analysis;
Chromatograpy,high pressure liquid
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2015;(3):489-493
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of heating temperature and heating time on the dissolution characteristics of phenolic acids in water extract of Danshen Decoction. Methods The contents of tanshinol, protocatechuic aldehyde and salvianolic acid B in water extract of Danshen Decoction were determined by reverse-phase high performance liquid chromatography (RP-HPLC) . The changes of the contents were monitored by classic constant temperature acceleration method. Results Of the three components, the content of salvianolic acid was decreased with the increase of heating temperature and the prolongation of heating time, and the degradation characteristics of the salvianolic acid B met the first-order kinetics equation. Conclusion The water-soluble components have less stability in the water extracts of Danshen Decoction. Lignum Santali Albi and Fructus Amomi accelerate the degradation speed of Radix Salviae Miltiorrhizae, suggesting that we should pay attention to the influence of heating temperature and heating time on the content of salvianolic acid B in the extraction and concentration process.
