Detection of expressions of Ck2α,β-catenin and survivin in ovarian cancer tissue and its clinical application value
10.13481/j.1671-587x.20140627
- VernacularTitle:Ck2α、β-catenin和survivin在卵巢癌组织中表达的检测及其临床应用价值
- Author:
Shuang WU
;
Yimeng LIU
;
Chao LIU
;
Lin GUO
;
Jianying XIAO
- Publication Type:Journal Article
- Keywords:
casein kinase 2α;
β-catenin;
survivin;
ovarian neoplasms
- From:
Journal of Jilin University(Medicine Edition)
2014;(6):1256-1260
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of casein kinase 2α(Ck2α),β-catenin, survivin in ovarian cancer tissue and analyze the relationships between them, and to explore the clinical application value. Methods Immunohistochemistry staining was used to detect the expressions of Ck2α,β-catenin and survivin in 8 cases of simple ovarian cysts tissue,8 cases of ovarian benign tumor tissue and 29 cases of ovarian cancer tissue;the correlations of the expressions of Ck2α,β-catenin,survivin in ovarian cancer tissue and their associations with the clinicopathologic characteristics were analyzed.Results The expression levels of Ck2α,β-catenin and survivin in ovarian cancer tissue were significantly higher than those in simple ovarian cysts tissue and ovarian benign tumor tissue(P<0.05);the Ck2αexpression level in ovarian cancer tissue was positively corelated with the expression levels ofβ-catenin and survivin(r=0.438,r=0.479,P<0.05);the expression levels of Ck2α,β-catenin and survivin in low-medium differentiation group were significantly higher than those in high differentiation group (P<0.05);the expression levels of Ck2α,β-catenin and survivin in stagesⅡandⅢ group were significantly higher than those in stage Ⅰ group(P<0.05).Conclusion The protein expression levels of Ck2α,β-catenin and survivin are increased in ovarian cancer tissue, and three are positive corelations between them;Ck2α,β-catenin and survivin may play an important role in the occurrence and development of ovarian cancer;the combined detection of them has important clinical value.
