Efficacy and safety of combination treatment with triamcinolone acetonide retrobulbar inj ection and panretinal photocoagulation in diabetic macular edema
10.13481/j.1671-587x.20140634
- VernacularTitle:球后注射曲安奈德联合全视网膜光凝治疗糖尿病性黄斑水肿的疗效及安全性评价
- Author:
Shuyan LI
;
Lin MIAO
;
Han CHEN
;
Shasha LIU
- Publication Type:Journal Article
- Keywords:
retrobulbar inj ection;
triamcinolone acetonide;
diabetic retinopathy;
macular edema;
panretinal photocoagulation
- From:
Journal of Jilin University(Medicine Edition)
2014;(6):1289-1292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the efficacy and safety of triamcinolone acetonide (TA)retrobulbar injection combined with panretinal photocoagulation (PRP)in the treatment of diabetic macular edema (DME), and to explain the advantages of this combination treatment method in treating DME.Methods Sixty-four cases (64 eyes) with macular edema due to diabetic retinopathy(DR)were randomly divided into combination treatment group(n=34,treated with TA retrobulbar injection combined with PRP)and PRP group(n=30,received PRP treatment only).The changes in the best corrected visual acuity (BCVA), the fovea centralis thickness (CMT), and the intraocular pressure(IOP)before treatment and in 1 month, 3 months, 6 months after treatment were compared. Results The BCVA was improved in both groups after treatment. However, the BCVA improvement in combination treatment group was statistically more significant (P<0.05)compared with PRP group in 1 month, 3 months and 6 months after treatment. The resolution of DME after treatment as compared with that before treatment,the CMT reduced in two groups in 1 month,3 months,6 months after treatment.At each stage,the CMT in combination treatment group was lower than PRP group (P<0.05 ). No complications of glaucoma, cataract,vitreous hemorrhage,retinal detachment,choroidal detachment,and endophthalmitis were found in all patients.Conclusion For the patients with DME,the combination treatment with TA retrobulbar injection and PRP has a better therapeutic effect than the sole PRP treatment in reducing the macular edema and improving the BCVA.The operation is simple and has less complication.
