Comparison of clinical effects between laparoscopic Nissen fundoplication combined with highly selective vagotomy and traditional laparoscopic Nissen fundoplication in treatment of gastroesophageal reflux disease
10.13481/j.1671-587x.20140632
- VernacularTitle:腹腔镜 Nissen胃底折叠术联合高选择性迷走神经切断术与传统腹腔镜 Nissen胃底折叠术治疗胃食管返流病的临床疗效比较
- Author:
Hong ZHANG
;
Hezhen LU
;
Zhihong LI
;
Kaizhong WANG
;
Ping REN
;
Tong FU
- Publication Type:Journal Article
- Keywords:
laparoscopic Nissen fundoplication;
gastroesophageal reflux disease;
peptic ulcer;
highly selective vagotomy
- From:
Journal of Jilin University(Medicine Edition)
2014;(6):1280-1284
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical effects of laparoscopic Nissen fundoplication (LNF)combined with highly selective vagotomy(HSV)(LNFHSV)in treatment of gastroesophageal reflux disease(GERD),and to provide reference for the clinical application of LNFHSV.Methods 22 patients with a history of GERD unrelieved by medication and underwent LNFHSV were selected.At the same time ,36 patients with GERD underwent LNF were used as control.The mean operation time,hospital stay,incidence of main operative complications,HSS complete remission and Demeester scores of the patients in two groups were retrospectively analyzed.Results The Demeester scores,hospital stay, incidence of main operative complications of the patients in two groups before operation had no significant differences(P>0.05).The mean operation time in LNFHSV group (90 min±35 min) was longer than that in LNF group(65 min± 21 min).The Demeester scores of the patients in two groups after operation had significant difference(P<0.05).The HSS complete remission rate of the patients in LNFHSV group was 91.1%,the part remission rate was 8.9%,and no effectiveness was 0;they were 83.3%,13.8%,and 2.8% in LNF group;there were significant differences between two groups(P<0.05).Conclusion LNFHSV has better effectiveness in controlling GERD than LNF procedure.
