Role of microRNAs in carcinogenesis and development of gastric cancer
10.3760/cma.j.issn.1673-4203.2015.11.019
- VernacularTitle:microRNA在胃癌中研究进展
- Author:
Jianning SONG
;
Zhigang BAI
;
Jie YIN
;
Jun CAI
;
Xuemei MA
;
Zhongtao ZHANG
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Stomach neoplasms;
Proliferation;
Apoptosis;
Chemotherapy resistance;
Review
- From:
International Journal of Surgery
2015;42(11):775-779
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) , a species of small noncoding RNA, could regulate gene expression bv binding to the 3'-untranslated region of target mR NA at post-transcription level.MicroRNAs play important roles in various human biological processes such as differentiation, cell proliferation, and apoptoMs.Abnormal expression of miRNAs is implicated in carcinogenesis and progression of various cancers, indicating that miRNAs could be served as molecular biomarkers for diagnosis and treatment of cancer.In this resiew, the author summarize the most common altered miRNAs expression profiles and their possible roles in promoting cell proliferation, tumor metastasis,and chemotherapeutic resistance in gastric cancer.
