Clinical efficacy of Tanreqing Injection in treatment of acute irradiationmucosal injury in patients with head and neck cancer
10.13481/j.1671-587x.20140535
- VernacularTitle:痰热清注射液治疗头颈部肿瘤急性放射性黏膜损伤的临床疗效
- Author:
Xiong HUANG
;
Chuanshu CAI
- Publication Type:Journal Article
- Keywords:
Tanreqing Inj ection;
radiation;
mucosal inj ury;
head and neck neoplasms;
stomatitis and layngophargngitis
- From:
Journal of Jilin University(Medicine Edition)
2014;(5):1090-1092
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect of Tanreqing Injection in treatment of acute irradiation oropharyngeal mucositis in the patients with head and neck cancer, and to provide reference for its clinical application.Methods Fifty patients with head and neck cancer were randomly divided into treatment group and control group(n=25).The patients in treatment group received concurrently intravenous infusion of Tanreqing Inj ection during irradiation course.The patients in control group received daily regular oral nursing;oropharyngeal mucositis was evaluated according to the protocol proposed by RTOG.Results The patients in treatment group with Ⅰ and Ⅱ oropharyngeal mucosal injury accounted for 76%,and the patients in control group with Ⅲ,Ⅳoropharyngeal mucosal injury accounted for 60%,there was statistically significant difference between two groups (P<0.05).The scores of the patients with oropharyngeal pain in treatment group were 0-3 (mild),in control group they were 4- 6 (moderate).The patients with mild,moderate,and severe oropharyngeal pain in treatment group and control group after radiotherapy accounted for 72%,24%,4% and 12%,64%,24%;there were statistically significant differences between two groups (P<0.05).Conclusion Tanreqing Injection has a good therapeutic effect on acute radiation stomatitis and layngopharyngitis, and it has the effects of relieving oral and pharyngeal mucosa inj ury,anti-inflammatory and analgesic and accelerating wound healing.
