Meta-analysis on association between smoking and p53 gene mutation in patients with lung cancer

VernacularTitle:肺癌患者吸烟与p53基因突变关联性的Meta分析
Author: Xuejun LIN ; Kangkang YAN ; Longyu ZHAO ; Honghong BAO ; Shuang LI ; Xiaodong LIU ; Xin LIU
Publication Type:Journal Article
Keywords: lung neoplasms; smoking; p5 3 gene mutation; Meta-analysis
From: Journal of Jilin University(Medicine Edition) 2014;(5):1046-1050
CountryChina
Language:Chinese
Abstract: Objective To evaluate the relationship between smoking and p53 gene mutation in the lung cancer patients with Meta-analysis.Methods PubMed,Web of Science,ProQest and Medline were used to search all the relevant studies about the association between smoking and p53 gene mutation in the patients with lung cancer. Based on reviewing full text,the studies were selected and evaluated and the data was extracted.Statistical analysis was performed with Stata 1 2.0 software including the heterogeneity inspection, publication bias assessment, sensitivity analysis,effect consolidating and cumulative Meta-analysis.Results Totally 15 articles with 1 770 lung cancer patients were identified. 69.6% of the patients were smokers,30.4% were non-smokers.Overall,the smokers with lung cancer had a 2.70-fold higher risk for p53 gene mutation than the non-smokers with lung cancer (OR=2.70,95%CI=2.04-3.59).Conclusion p53 gene mutation is associated with smoking in the patients with lung cancer.The smokers with lung cancer have higher risk for p53 mutation than non-smokers.