Comparison of dosimetric parameters of re-irradiation in patients with locally recurrent nasopharyngeal carcinoma
10.13481/j.1671-587x.20140534
- VernacularTitle:局部复发鼻咽癌患者再程放疗技术的剂量学参数比较
- Author:
Mao ZHANG
;
Qingxiu SU
;
Jinlei YANG
;
Haiguo JIN
;
Ying DONG
;
Dan WU
;
Fuxiang WANG
- Publication Type:Journal Article
- Keywords:
nasopharyngeal neoplasms;
tumor recurrence;
dosimetric parameter;
volumetric modulated arc radiotherapy;
intensity modulated radiotherapy;
3-dimensional conformal radiotherapy
- From:
Journal of Jilin University(Medicine Edition)
2014;(5):1085-1089
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the dosimetric parameters of volumetric modulated arc therapy(VMAT),fixed field intensity modulated radiation therapy(IMRT)and three-dimensional conformal radiotherapy(3D-CRT)in the radiotherapy for the patients with locally recurrent nasopharyngeal carcinoma, and to analyze their characteristics. Methods Twelve patients with locally recurrent nasopharyngeal carcinoma were treated with VMAT, IMRT and 3D-CRT plan designed by Pinnacle 9.2 and Preciseplan 2.03 treatment planning system.The dosimetric parameters of targeted volumes and organs at risk were compared between three groups. Results The conformation indexes (CI)of VMAT and IMRT plans were similar,and they were both better than 3D-CRT plan,the difference was significant(P<0.05).The homogeneity index(HI)in three groups were similar,there were no statistically significant differences between them(P>0.05).The monitor units(MU)and beam time in 3D-CRT group were better than those in other two groups,and VMRT group was better than IMRT group,the statistical differences were observed between three groups (P<0.05 ).There were no statistical differences of organs at risk such as brainstem and lens between three groups(P>0.05).The doses of the spinal cord,optic nerve,optic chiasm and temporal lobe of brain in VMAT and IMRT groups were better than those in 3D-CRT group,there were statistical differences between them(P<0.05),and the data in VMAT and IMRT groups were similar,and there were no statistical differences(P>0.05).Conclusion There are differences of the targeted dose distribution between the three kinds of radiation technology, while VMAT and IMRT plans can cover the targeted areas and reduce the received doses of organs at risk.The CI,MU and beam time of VMAT plan are better than those of IMRT plan. 3D-CRT plan only has advantage in the MU and beam time.
