Research progress of TERT promoter mutation in thyroid carcinoma
10.3760/cma.j.issn.1673-4203.2015.11.017
- VernacularTitle:TERT启动子突变在甲状腺癌中的研究进展
- Author:
Detao YIN
;
Kun YU
- Publication Type:Journal Article
- Keywords:
Thyroid Neoplasms;
Diagnosis;
Prognosis;
Telomerase reverse transcriptase promoter mutation
- From:
International Journal of Surgery
2015;42(11):768-771
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid carcinoma is the most frequent endocrine cancer.Recently, it has been discovered that telomerase reverse transcriptase promoter mutation can prevent cell tolemeres from shortening, leading to cell immortalization and plays an important role in the tumor genesis, invasiveness and metastasis of the thyroid carcinoma.Testing of telomerase reverse transcriptase promoter mutation is of great value in diagnosis, which also can be used as a prognostic maker of thyroid carcinoma.
