Clinical Observation of Yingliu Mixture Combined with Methimazole for Treatment of Graves’ Disease
10.13359/j.cnki.gzxbtcm.2014.05.004
- VernacularTitle:瘿瘤合剂联合甲巯咪唑改善弥漫性毒性甲状腺肿的自身抗体的临床疗效观察
- Author:
Hua YANG
;
Hong TANG
;
Xiaojuan BI
;
Juanhua ZENG
;
Tengfei WU
;
Yilei CONG
- Publication Type:Journal Article
- Keywords:
Graves’ disease/TCM-wm therapy;
Yingliu mixture;
Methimazole tablets;
Thyroid function;
Autoantibodies
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2014;(5):706-711
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Yingliu mixture combined with methimazole on autoantibodies and traditional Chinese medical syndromes of patients with Graves’ disease ( GD) . Methods A randomized, paralleled and controlled trial was carried out in 92 GD patients. The patients were evenly randomized into treatment group and control group, and were separately treated with Yingliu mixture combined with methimazole, and methimazole. The treatment for both groups lasted 12 weeks, and forty patients in each group completed the whole treatment. The changes of thyroid function, thyroid autoantibodies, and traditional Chinese medical syndrome scores were observed before and after treatment, and the clinical efficacy was also evaluated. Results (1) After treatment for 12 weeks, serum levels of thyroid peroxidase antibody (TPOAb), thyroglobulin antibody ( TGAb) and thyrotrophin receptor antibody ( TRAb) were decreased, and thyroid stimulating hormone ( TSH) was increased obviously in both groups after treatment ( P<0.01 compared with those before treatment) . The treatment group has better effect on improving TGAb and TRAb than the control group ( P<0.05). ( 2) Compared with those before treatment, the total scores of clinical symptoms and signs were decreased in the two groups at different time points of treatment course ( P<0.001) , and the decrease value in the treatment group was larger than that in the control group ( P<0.05) . ( 3) The total effective rate of the treatment group was 92.50%, higher than 82.50% of the control group ( P<0.05) . Conclusion Yingliu mixture combined with methimazole is effective on improving thyroid function, decreasing autoantibodies levels and relieving clinical symptoms and signs, and has better effect than methimazole alone for the treatment of GD.
