Huaiqihuang granule in adjuvant treatment of childhood asthma:a randomized controlled,multicenter study
10.3760/cma.j.issn.1673-4408.2016.02.015
- VernacularTitle:槐杞黄颗粒辅助治疗儿童哮喘的随机对照多中心临床研究
- Author:
Xiang LI
;
Yunxiao SHANG
;
Huanji CHENG
;
Shaomin REN
;
Yan HUANG
;
Jicheng DAI
;
Shuqiang QU
;
Guangli ZHENG
;
Chunmei JIA
;
Zhiying HAN
;
Huaiqing YIN
;
Xuxu CAI
;
Xiaohua HAN
;
Jirong LU
;
Hongmei QIAO
- Publication Type:Journal Article
- Keywords:
Asthma;
Huaiqihuang;
Children;
Randomized controlled trial;
Multicenter study;
C-ACT
- From:
International Journal of Pediatrics
2016;43(2):145-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy and safety of GINA regimen and GINA regimen combined with oral Huaiqihuang granule in the treatment of children with bronchial asthma.Methods A ran-domized,single blind,multicenter,parallel controlled clinical trial wascarried out.A total of 1 128 patients with bronchial asthma in children were randomized into two groups.The observation group were treated with GINA regimen combined with oral Huaiqihuang granule.The GINA regimen treatment group was treated by GINA reg-imen.Clinical assessment and C-ACT scores was observed in first month,third month,sixth month after treat-ment.Clinical assessment included the times of upper respiratory tract infection occurrence,bronchitis and pneu-monia,asthmatic attacks,application of emergency medicine,hospitalizations due to asthmatic.Drug adverse effect in the two groups was compared.Results The times of upper respiratory tract infection,bronchitis and pneumonia,asthmatic was significantly decreased(P <0.05 ),and C-ACTscores were significantly higher(P <0.05)in the first month,the third month,and the sixth month after treatment.There were 16 cases of drug relat-ed adverse reactions.Seven cases were in observation group(n ﹦7)(1.15%)and 9 cases in the GINA regimen treatment group(n ﹦9)(1.73%).There was no significant difference of adverse effect between the two groups (P >0.05).Conclusion The treatment of bronchial asthma in children with GINA regimen combined with oral Huaiqihuang granule can significantly reduce the incidence of respiratory infections and the number of asthmatic attacks dramatically and safely improve clinical curative effect,asthma control.
