Clinical features of osteonecrosis of jaws after bisphosphonates therapy for bone me-tastasis of breast cancer
10.3969/j.issn.1671-167X.2016.01.014
- VernacularTitle:二膦酸盐药物治疗乳腺癌骨转移发生颌骨坏死的临床特点
- Author:
Yuxing GUO
;
Diancan WANG
;
Yang WANG
;
Xin PENG
;
Chi MAO
;
Chuanbin GUO
- Publication Type:Journal Article
- Keywords:
Diphosphonates;
Osteonecrosis;
Jaw;
Neoplasm metastasis
- From:
Journal of Peking University(Health Sciences)
2016;48(1):80-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the clinical features of osteonecrosis of the jaw after bisphospho-nates use for therapy of breast cancer patients with bone metastasis.Methods:The cases diagnosed as bisphosphonates-related osteonecrosis of the jaws (BRONJ)were retrospectively analyzed from January 201 1 to August 201 5 in the Peking University School and Hospital of Stomatology,and those breast cancer patients with bone metastasis were selected.The clinical symptoms,imaging characteristics and treatment results were summarized.Results:A total of 1 4 cases of breast cancer patients with bone me-tastasis were selected,with an average age of 60.21 years.The average time of suffering from breast cancer was 9 .77 years,and the average time of bone metastasis and bisphosphonates drugs use was 5 .67 and 3 .29 years individually.There was no patient with systemic application history of hormone therapy, and no history of diabetes.There were 9 patients with tooth extractions history,and the mean time of bone necrosis symptoms was 8.58 months.There were 1 0 cases with bone necrosis occurring on mandi-ble,3 cases on maxilla,and one case with both upper and lower jaws involved.Among the 1 0 patients with surgical treatment,there were 3 cases cured,and 6 cases improved.However,the clinical symp-toms of 2 cases with conservative treatment were significantly aggravated.Conclusion:The medication time between the bisphosphonates use beginning and the occurrence of BRONJ is relatively long.The his-tory of diabetes and long-time hormone use did not exist in this group.Tooth extraction itself does not de-termine the severity of BRONJ.Mandible is the most common site involved by BRONJ.Surgical treatment can alleviate the clinical symptoms of BRONJ with breast cancer to some extent.
