Innate immune cell-derived IL-l7 mediating organ ischemia reperfusion injury
10.3760/cma.j.issn.1673-4408.2016.02.007
- VernacularTitle:固有免疫细胞源性 IL-17导致器官再灌注损伤的研究进展
- Author:
Zheng ZOU
;
Yu PENG
;
Dawei ZOU
- Publication Type:Journal Article
- Keywords:
Innate Immune;
IL-17;
Ischemia Reperfusion Injury;
Organ
- From:International Journal of Pediatrics
2016;43(2):113-118
- CountryChina
- Language:Chinese
-
Abstract:
IL-17,as a pro-inflammatory cytokine,is one of the early initiation factors of the inflammato-ry response induced by T cells.It can induce and regulate multiple immune responses.Recent studies have re-vealed that myeloid neutrophils,macrophage,mast cell and other innate immune cells all can secrete large a-mount of early responding IL-17 in organs suffering ischemia/hypoxia,and in turn can activate,amplify and re-cruit neutrophils to the reperfusion-damaged tissue to release large amount of free radicals and lysozyme that cause IRI.Researchers have also provided evidence that appropriate administration of anti-IL-17 mono-antibody to neutralize IL-17 during early reperfusion stage would reduce the tissue damage.The purpose of this review is to summarize the research progress of the effects of IL-17 produced by innate immunocyte on organ reperfusion injury.
