Clinical application of zinc finger protein A20
10.3760/cma.j.issn.1006-9801.2015.11.022
- VernacularTitle:锌指蛋白A20的临床应用
- Author:
Xiaoqing FAN
;
Yinglan ZHANG
- Publication Type:Journal Article
- Keywords:
Zinc fingers;
Apoptosis;
Inflammation
- From:
Cancer Research and Clinic
2015;27(11):791-792
- CountryChina
- Language:Chinese
-
Abstract:
Pathologist Dixit in American Michigan University found a gene induced by cytokine from human umbilical vein endothelial cells in 1990.This gene is increased in a variety of cells rapidly and coded a special kind of the zinc finger protein when being stimulated by interleukin-1 (IL-1),PLS and tumor necrosis factor (TNF).The gene was named as zinc finger protein A20 gene,and its coding protein was named as zinc finger protein A20.A20 is a kind of endogenous regulatory protein,inhibiting the inflammatory reaction and cell apoptosis through the inhibition of NF-kappa B activity.This article mainly reviewed the structure,function and clinical significance of A20.
