Toll-like receptors in hematological malignancies
10.3760/cma.j.issn.1006-9801.2015.11.021
- VernacularTitle:Toll样受体与血液恶性肿瘤
- Author:
Xinxing YAN
- Publication Type:Journal Article
- Keywords:
Toll-like receptors;
Lymphoma;
Leukemia;
Tumor immunology
- From:
Cancer Research and Clinic
2015;27(11):788-790
- CountryChina
- Language:Chinese
-
Abstract:
The Toll-like receptors are a kind of pattern recognition receptors,which are expressed in a variety of cells,playing an important role in innate immunity and subsequent acquired immunity.At the same time,they are also involved in the immunity,proliferation,apoptosis and other physiological processes of the cells.Toll-like receptors are also expressed in hematological malignancies and involved in the progress of tumor development,immune escape,resistance,which play a double-edged sword role.In this paper,basic knowledge of TLR molecule and study on hematological tumor were mainly reviewed,aiming to provide a train of thoughts for the treatment of hematologic malignancies.
