Evaluation on effectiveness of salmeterol/fluticasone propionate combined with N-acetylcysteine in treatment of chronic obstructive pulmonary disease
10.13481/j.1671-587x.20140436
- VernacularTitle:沙美特罗／丙酸氟替卡松联合N-乙酰半胱氨酸治疗慢性阻塞性肺疾病的疗效评价
- Author:
Xiaoguang XU
;
Zhenyu JIANG
;
Minjuan DU
;
Yaqin YANG
;
Yingchao JIANG
- Publication Type:Journal Article
- Keywords:
salmeterol/fluticasone propionate;
N-acetylcysteine;
chronic obstructive pulmonary disease;
pulmonary function test;
blood gas analysis
- From:
Journal of Jilin University(Medicine Edition)
2014;(4):870-874
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of salmeterol/fluticasone propionate complicated or combined with N-acetylcysteine on the pulmonary function and arterial blood gas analysis of the patients with chronic obstructive pulmonary disease (COPD), and to evaluate its curative effect.Methods 84 cases of COPD patients were randomly divided into combination treatment group (n=44)and simple treatment group (n=40).The patients in combination treatment group were treated with salmeterol/fluticasone propionate combinated with N-acetylcysteine while the patients in simple treatment group were treated only with salmeterol/fluticasone propionate, both of which were followed up for 6 months.The changes of pulmonary function (FEV1%FVC,FEV1%Pred,PEF daily variation rate:ΔPEF%)and the arterial blood gas analysis indexes (PaO2 and PaCO2 )of the patients in two groups were recorded before treatment, 3 months after treatment, and 6 months after treatment. Results The FEV1%FVC,FEV1%Pred and PaO2 of the patients in combination treatment group and simple treatment group were obviously increased 3 and 6 months after treatment compared with before treatment (P<0.01 ), and the PaCO2 were obviously decreased (P<0.01).And there were significant differences of the indexes mentioned above of the patients between two groups (P<0.05 );but the indexes of each group had no significant differences between 3 months and 6 months after treatment (P>0.05).TheΔPEF% of the patients in two groups had no significant differences between inter-group and intra-group before and after treatment (P > 0.05 ). Conclusion Combination of salmeterol/fluticasone propionate and N-acetylcysteine can obviously improve the pulmonary function and arterial blood gas analysis indexes of the COPD patients, which is superior to the simple application of salmeterol/fluticasone propionate and has definite and lasting curative effect on the treatment of COPD.
