Correlation of Traditional Chinese Medical Syndrome Elements with Plasma Connective Tissue Growth Factor and Platelet-derived Growth Factor in Early Liver Cirrhosis Induced by Type B Hepatitis
10.13359/j.cnki.gzxbtcm.2015.01.002
- VernacularTitle:早期乙型肝炎肝硬化中医证素特征及其与血浆CTGF、 PDGF的相关性研究
- Author:
Yao LIU
;
Tongyu WU
;
Dongliang LI
;
Jianying SHEN
;
Lingyuan ZHANG
;
Shanshan DING
;
Zhiping SHI
;
Xiangjun CHEN
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis induced by type B hepatitis;
Syndrome elements;
Connective tissue growth factor;
Platelet-derived growth factor
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2015;(1):4-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of traditional Chinese medical syndrome elements with plasma connective tissue growth factor ( CTGF) and platelet-derived growth factor ( PDGF) in early liver cirrhosis induced by type B hepatitis. Methods The distribution of traditional Chinese medical syndrome elements in early liver cirrhosis induced by type B hepatitis was analyzed, plasma contents of CTGF and PDGF were detected by enzyme-linked immunosorbent assay ( ELISA) , and the correlation of syndrome elements with CTGF and PDGF was discriminated. Results ( 1) The distribution of traditional Chinese medical syndrome elements in early liver cirrhosis induced by type B hepatitis showed as follows: the syndrome elements involved the viscera of liver and spleen, and the pathogenesis was characterized as dampness, heat, qi stagnation, and yin deficiency. ( 2) CTGF was closely related with spleen, gallbladder and dampness, with OR value being 1.598, 1.567, 2.797, respectively. PDGF was closely related with heat, with OR value being 1.134. Conclusion Early liver cirrhosis induced by type B hepatitis mainly affects the viscera of liver and spleen, the pathogenesis is characterized by dampness, heat, qi stagnation, and yin deficiency. The patients with higher CTGF are apt to show the pathological changes of spleen, gallbladder, dampness, and have the syndrome el-ements of spleen, gallbladder, dampness. The patients with higher PDGF are apt to show the pathological changes of heat, and have the syndrome element of heat.
