Roles and mechanisms of β-catenin in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2015.11.013
- VernacularTitle:β-连环蛋白在脑缺血中的作用及其机制
- Author:
Dandan LIU
;
En XU
- Publication Type:Journal Article
- Keywords:
β Catenin;
Brain Ischemia;
Apoptosis;
Neurogenesis;
Blood-Brain Barrier;
Neuroprotective
- From:
International Journal of Cerebrovascular Diseases
2015;23(11):870-876
- CountryChina
- Language:Chinese
-
Abstract:
β-Catenin is an adhesion molecule that mediates intercellular adhesion.It can be activated by the classical Wnt signaling pathway and promote cell survival.During cerebral ischemia,the stability of β-catenin decreases and the phosphorylated β-catenin level increases.Up-regulation of β-catenin can inhibit the schemia-induced neuronal apoptosis,promote neurogenesis,maintain the stability of blood-brain-barrier,and protect against cerebral injury.
