The expression and clinical significance of interleukin -6 in non -Hodgkin's lymphoma
10.3760/cma.j.issn.1008-6706.2015.24.034
- VernacularTitle:非霍奇金淋巴瘤中白细胞介素-6的表达及其临床意义
- Author:
Yang ZHOU
;
Weili ZHAO
;
Pengpeng XU
;
Xia ZHAO
- Publication Type:Journal Article
- Keywords:
Lymphoma,non -Hodgkin;
Lymphoma,diffuse;
Lymphoma,follicular;
Interleukin -6
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(24):3783-3786
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of interleukin -6 (IL -6)in aggressive and indolent lymphoma patients.Methods Serum specimens obtained from 1 07 non -Hodgkin's lympho-ma (NHL)patients and 50 healthy controls were collected.Chemiluminescence immunoassay was used to assess the expression of IL -6 in the serum.Results The level of serum IL -6(1 8.54 ±4.53)ng/L in aggressive lymphoma group was significantly higher than (6.90 ±1 .78)ng/L in the inert lymphoma group,and the serum IL -6 levels of two groups were significantly higher than the healthy control group (3.87 ±0.76)ng/L.The lymphoma patients,with B symptoms,elevated CRP or bone marrow involvement presented higher IL -6 level than the other patients (P <0.05).IL -6 level of the IPI high -risk group was higher than the intermediate -risk group and low -risk group, with significant difference (P <0.05 ).The correlation study showed that IL -6 and CRP,IPI /FLIPI,Ann Arbor stage,B symptoms,bone marrow involvement had significantly positive correlation (P <0.05);Through analysis of the effect of the patients with aggressive lymphoma,the serum level of IL -6 in patients with complete remission was sig-nificantly higher than the non complete remission group.By Logistic regression analysis,IL -6 was one of the inde-pendent risk factors affecting the treatment effect of NHL,and the difference was statistically significant (P <0.05). Conclusion The serum IL -6 was significantly elevated in NHL patients,in association with tumor invasion,progno-sis and therapeutic effect.IL -6 may help the diagnosis and prognosis of NHL.
