Application of 18 FDG PET/CT in diagnosis of ectopic ACTH syndrome induced by lung cancer
10.13481/j.1671-587x.20150634
- VernacularTitle:18 FDG PET／CT 在肺癌致异位 ACTH 综合征诊断中的应用
- Author:
Xin CHENG
;
Yanru MA
;
Yimin LIU
;
Yonghong DANG
;
Haiqun XING
;
Nan HU
- Publication Type:Journal Article
- Keywords:
lung neoplasms;
pulmonary carcinoid;
Cushing syndrome;
ectopic adrenocorticotrophic hormone syndrome;
positron emission tomography;
18 F-fluorodeoxyglucose
- From:
Journal of Jilin University(Medicine Edition)
2015;(6):1275-1278
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of 18 F-fluorodeoxyglucose (18 FDG)positron emission tomography and computer tomography (PET/CT)in the diagnosis and localization of ectopic ACTH syndrome (EAS)induced by lung cancer,and to increase the accuracy rate of diagnosis of EAS.Methods 8 patients were histopathologically proven to be lung cancer.18 FDG PET/CT wholebody and brain scan were performed;magnetic resonance imaging (MRI),99m Tc-octreotide (OCT)imaging and inferior petrosal sinus sampling (IPSS)were done in all patients.On 18 FDG PET/CT images,the SUVmax values of lesions and the SUVmax ratio of lesion tissue to normal lung tissue were calculated.Results ① 8 patients with EAS included 2 cases of carciniod,4 cases of atypical carciniod,and 2 cases of small cell lung cancer.The ACTH levels in inferior petrosal sinus and peripheral veins of 8 patients had no difference.②The chest CT showed there were pulmonary nodules in 6 cases (75%),among them 2 cases were atypical lesions.5 cases of pituitary adenomas were found by MRI (25%),and OCT imaging was positive in 2 cases (25%).③The 18 FDG PET/CT showed nodular,mass like or patch samples with high metabolic activity in 8 cases (100%)of pulmonary lesions.The SUVmax of tumor was 0.72 to 14.05 (3.67±4.68),and the ratio of SUVmax of lesion tissue to normal lung tissue was 1.69 to 27.54 (8.14 ± 9.63).18 FDG hypermetabolism was found in 8 cases of bilateral adrenal hyperplasia,while 4 cases showed pituitary tumor.Conclusion Lung cancer is a common source of EAS,especially carcinoid.18 FDG PET may show lower glucose metabolism.18 FDG PET/CT should be used as an assisted method to diagnose EAS.
