Advances in radiotherapy combined with EGFR-TKIs for non-small cell lung cancer
10.3969/j.issn.1000-8179.2015.23.846
- VernacularTitle:放疗联合EGFR-TKIs治疗非小细胞肺癌新进展
- Author:
Kan WU
;
Bing WANG
;
Bing XIA
;
Shirong ZHANG
;
Shenglin MA
- Publication Type:Journal Article
- Keywords:
NSCLC;
radiotherapy;
EGFR-TKI
- From:
Chinese Journal of Clinical Oncology
2015;(23):1113-1117
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is the main cause of cancer-related death worldwide. Non-small cell lung cancer (NSCLC) accounts for about 80% of lung cancer cases, but only 25%-30% of initially diagnosed patients have the option of radical surgery because of the lack of effective measures for early diagnosis. For locally advanced and advanced NSCLC, radiotherapy alone or comprehensive treatment with chemoradiotherapy is the main treatment method; however, the curative effect is unsatisfactory. Recently, increasing evidence sug-gests that targeted drugs, such as epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), combined with radiotherapy/chemoradiotherapy represent a promising treatment modality for NSCLC. This review will discuss the research status of EGFR-TKIs and radiotherapy for locally advanced and advanced NSCLC.
