The 50% effective dose of dexmedetomidine for sedation in the brachial plexus block
10.3760/cma.j.issn.1673-4904.2015.11.009
- VernacularTitle:右美托咪啶用于臂丛神经阻滞的半数镇静有效剂量
- Author:
Qiaoqiao YAN
;
Qigang YE
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Sedation;
50％effective dose;
Auditory evoked potential index
- From:
Chinese Journal of Postgraduates of Medicine
2015;(11):810-812
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the 50%effective dose (ED 50) of dexmedetomidine for sedation in the brachial plexus block, so as to provide reference for clinical. Methods Twenty-three patients underwent the brachial plexus block using an ultrasound guided technique. After blocked for 30 min, the dexmedetomidine was infused by a intravenous continuous pump,and an observer' s assessment of alertness/sedation score (OAA/S) and auditory evoked potential index (AEPI) were used for monitoring the depth of sedation. The dexmedetomidine was adjusted according to the response of the previous patient using a up-and-down sequential method until the sequential response curve appeared seven fold points. The initial dexmedetomidine of the first patient was 1μg/kg. Each time the dosage increased/decreased by 0.1μg/kg. The OAA/S score of no more than 3 was defined an effective sedation. Results The ED50 of dexmedetomidine for sedation was 0.78μg/kg (95%CI 0.66-0.86μg/kg). The AAI was positively correlated to the OAA/S score, and linear regression equation was Y=-1.43+0.109 X, R2=0.919. Conclusion The ED50 of dexmedetomidine for sedation in the brachial plexus block is 0.78μg/kg (95%CI 0.66-0.86μg/kg).
