Value of microRNA-21 in diagnose of early gastric cancer
10.3760/cma.j.issn.1673-4904.2015.11.014
- VernacularTitle:微小RNA-21在早期胃癌诊断中的价值评价
- Author:
Xiaoling BAO
;
Hong FAN
- Publication Type:Journal Article
- Keywords:
MicroRNA-2;
Early gastric cancer;
Diagnosis;
Receiver operator characteristic curve
- From:
Chinese Journal of Postgraduates of Medicine
2015;(11):827-829
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnosis value of expression level of peripheral blood microRNA-21 in early gastric cancer patients. Methods In 52 patients with Tis gastric cancer and 40 healthy subjects, expression levels of microRNA-21 in peripheral blood were quantitatively detected by real-time quantitative PCR(qRT-PCR),and diagnostic value of expression level of microRNA-21 in peripheral blood were evaluated by receiver operator characteristic (ROC) curve. Results Relative quantity expression level of microRNA-21 in peripheral blood in gastric cancer group and healthy subjects group were 2.286±0.592 and 1.318±0.357, and there was statistical significance (U=136.500, P=0.000). ROC curve analysis showed that ROC curve area of expression level of microRNA-21 in peripheral blood in diagnosing gastric cancer was 0.934(95%CI 0.887-0.982, P=0.000), and the best diagnostic boundary point value was 1.912. The sensitivity of expression level of microRNA-21 in peripheral blood in diagnosing gastric cancer was 86.5%, and the specificity was 95.0%. Conclusion Expression level of microRNA-21 in peripheral blood has important diagnostic value in early gastric cancer.
