The effect of liver function on the awake BIS value
- VernacularTitle:肝功能 Child-Pugh 分级与清醒时 BIS 值的相关性
- Author:
Shaojun XU
;
Shiyang LI
;
Huaping XIONG
;
Mingkun SHEN
;
Weiyu YAO
- Publication Type:Journal Article
- Keywords:
Liver function dysfunction;
BIS;
Hyperbilirubinemia
- From:
The Journal of Clinical Anesthesiology
2015;(12):1205-1207
- CountryChina
- Language:Chinese
-
Abstract:
Objective The main objective of this study is to explore the effect of liver function on the awake BIS value.Methods According to the Child-Pugh classification,65 patients were divid-ed into three groups.Group A (n=27):patients with normal liver function;group B (n=21):pa-tients with Child-Pugh A;group C (n=1 7):patients with Child-Pugh B-C.The awake BIS value at rest was measured.Results Total bilirubin (TBIL),direct bilirubin (DBIL),indirect bilirubin (IBIL),alanine aminotransferase (ALT),aspartate aminotransferase (AST),albumin (ALB)of group B and C were significantly poorer than group A (P <0.05 or P <0.01).The coagulation func-tion of group C was poorer than group A and B (P <0.01).Compared with group A (96.2 ± 1.7) and group B (95.6±0.8),the awake BIS value of group C (94.1±3.0)was significantly reduced (P<0.01).The awake BIS value was negatively correlated with the TBIL value (r = - 0.26,P =0.039).Conclusion The awake BIS value in end-stage liver disease patients was significantly lower than that in patients with normal liver function and mild liver dysfunction.The awake BIS value may be related with the amount of total bilirubin in the blood.
