Effect of low molecular weight heparin combined with low dose aspirin on hormone level and immune function in patients with recurrent spontaneous abortion
- VernacularTitle:低分子肝素联合小剂量阿司匹林对复发性流产患者激素水平、免疫功能的影响
- Author:
Gao ZHANG
;
Linghui CHENG
- Publication Type:Journal Article
- Keywords:
recurrent spontaneous abortion;
low molecular weight heparin;
aspirin;
hormone levels;
immune function
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(11):67-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study effect of low molecular weight heparin combined with aspirin on hormone level and immune function in treatment of recurrent spontaneous abortion.Methods 118 cases patients with recurrent spontaneous abortion from January 2013 to December 2013 were divided into observation group and control group, control group was given low-dose aspirin therapy, observation group was given low molecular weight heparin combined with low-dose aspirin.hormone levels, immune function, therapy effect were compared between two groups.Result Clinical curative effect:observation group prevent miscarriage success rate 86.44% was significantly higher than control group 55.93%(χ2 =13.387, P<0.05); Hormone levels: observation group serum HCG, P, E2 levels were significantly higher than the control group(P<0.05); Immune function: observation group IFN-γ, IFN-γ/IL-4 were significantly lower than control group, IL-4 were significantly higher than the control group(P<0.05);Adverse reaction:there were no statistical differences of adverse reaction between two groups(22.03% vs 15.25%)(χ2 =0.894, P>0.05).Conclusion Low molecular weight heparin combined with aspirin therapy help to improve recurrent hormone levels and immune function, then improve prevent miscarriage success rate.
