The effect of dexmedetomidine on corrected QT and Tp-e interval in patients undergoing knee joint re-placement with spinal anesthesia
- VernacularTitle:右美托咪定对腰麻下膝关节置换术患者校正 QT间期和 Tp-e 间期的影响
- Author:
Wei WU
;
Zhaoduan LI
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Electrocardiogram;
Spinal anesthesia
- From:
The Journal of Clinical Anesthesiology
2015;(12):1183-1185
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of dexmedetomidine on corrected QT (QTc)and Tp-e interval from the peak of the T wave to the end of the T wave in patients undergoing knee joint replacement with spinal anesthesia.Methods Seventy patients 45-75 years,ASA Ⅰ or Ⅱ,who were scheduled to knee joint replacement with spinal anesthesia were divided into group C and group D ran-domly according to random number table (n=35 each group).Dexmedetomidine 0.6 μg/kg was ad-minstered over 10 min intravenously,followed by a continuous infusion at a dose of 0.4 μg·kg-1 · h-1 in group D and volume-matched normal saline infusion was adminstered in group C 1 5 min after spinal anesthesia.Time points for QT (QTc)and Tp-e intervals and hemodynamic parameters were:before spinal anesthesia (T0 ),5 (T1 ),10 (T2 ),and 1 5 (T3 )minutes after spinal anesthesia and 10 (T4 ),30 (T5 ),and 60 minutes (T6 )after infusion of dexmedetomidine or normal saline.The side effects in 24 h were also recorded.Results QTc intervals (T1-T3 )in both groups were significantly prolonged compared with T0 (P < 0.05 ).Compared with T3 ,QTc values in group D during T4-T6 were significantly shorter (P <0.05).QTc interval in group D during T4-T5 was significantly shorter than that in group C (P <0.05).There was no difference in side effects during postoperative 24 hours between two groups.Conclusion Dexmedetomidine could promote the return of a prolonged QTc in-terval in patients undergoing knee joint replacement with spinal anesthesia.
