Research Progress on Multiple Origins Theory of Epithelial Ovarian Carcinoma

VernacularTitle:卵巢上皮性癌多起源学说的研究进展
Author: Lili WANG ; Hongyan GUO
Publication Type:Journal Article
Keywords: Epithelial ovarian carcinoma; Fallopian tube origin; Multiple origins theory
From: Chinese Journal of Minimally Invasive Surgery 2015;(12):1117-1120
CountryChina
Language:Chinese
Abstract: [Summary] Epithelial ovarian carcinoma has the highest fatality rate among gynecologic malignant tumors.Lacking of effective early diagnosis and screening method are the main reasons for its poor prognosis.There is a close relationship between the heterogeneity of epithelial ovarian carcinoma and the diversity of cancerous origins.According to the traditional theory, epithelial ovarian carcinoma derives from germinal epithelium at ovarian surface.The “secondary Mullerian system” theory has challenged above view.This“dualism” theory completely subverts the traditional one.However, both of the theories have their limitations.In recent years, the multiple origins theory of epithelial ovarian carcinoma has gradually become a hot point of discussion.