Effect of protocatechuic acid on serum TNF-α, IL-1βand oxidative stress products levels in Parkinson rats
- VernacularTitle:原儿茶酸对帕金森模型大鼠血清TNF-α、IL-1β及氧化应激产物水平的影响
- Author:
Qiang ZHANG
;
You LIU
;
Zhonghai ZHANG
- Publication Type:Journal Article
- Keywords:
protocatechuic acid;
Parkinson disease;
rat;
tumor necrosis factor-α;
interleukin-1β;
oxidative stress
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(11):37-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of protocatechuic acid on serum tumor necrosis factor-α( TNF-α) , interleukin-1β( IL-1β) and oxidative stress products levels in Parkinson rats.Methods 60 male SD rats were randomly divided into normal control group ( n=10 ) , model group (n=10), madopar group (n=20) and protocatechuic acid group (n=20).Rat model with Parkinson disease were builded in model group, madopar group and protocatechuic acid group.Madopar group and protocatechuic acid group were given corresponding drug with a consecutive treatment of two weeks.After treatment,the serum TNF-α,malondialdehyde (MDA), superoxide dismutase (SOD) and IL-1βlevels were detected in all groups.Results Compared with normal control group, the serum TNF-α, IL-1βand MDA levels in model group were significantly higher, and SOD level was lower (P<0.05).Compared with model group, the serum TNF-α, IL-1βand MDA levels in madopar group pre-treatment were significantly lower, and SOD level was higher (P<0.05).There were no significant difference of serum TNF-α, IL-1β, MDA and SOD levels between madopar group and protocatechuic acid group.Conclusion The protocatechuic acid could significantly reduce the serum TNF-α, MDA and IL-1βlevels in Parkinson model rats, enhance the activity of SOD, which has protective effect on oxidative stress injury induced by Parkinson disease.
