Efficacy and safety of budesonide/formoterol single inhaler therapy versus budesonide inhaler plus formoterol inhaler in children with bronchial asthma
- VernacularTitle:布地奈德／福莫特罗粉吸入剂治疗儿童哮喘的疗效及安全性研究
- Author:
Haiying LIU
;
Rongna GENG
- Publication Type:Journal Article
- Keywords:
budesonide/formoterol single inhaler;
asthma;
efficacy;
child
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(11):73-75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy between budesonide/formoterol single inhaler therapy and budesonide inhaler plus formoterol inhaler in children with bronchial asthma.Methods In randomized, open, parallel-group trial, 80 cases of children with bronchial asthma in children asthma center of Children's Hospital of Hebei Province were divided into B/F group ( budesonide/formoterol single inhaler therapy ) and B +F group (budesonide inhaler plus formoterol inhaler), 40 cases in each group.All patients in B/F group inspired budesonide formoterol sing inspirator [80μg (budesonide)/4.5μg(formoterol)/snuff], and all patients in B+F group inspired budesonide(100μg/snuff) and formoterol(4.5μg/snuff), 1 snuff/time, respectively, both groups were treated with 2 times/d,12 weeks.The visual analog scale(VAS), lung function as forced expiratory volume in one second(FEV1)%, peak expiratory flow(PEF) and clinical symptoms were investigated.Results Compared with B+F group in the same time period, PEF% and FEV1%on the 12th week were higher, VAS score on the 4th, 8th and 12th week were lower, symptoms scores on 8th and 12th were lower in B/F group, respectively(P<0.05).Conclusion The efficacy of budesonide/formoterol single inhaler therapy is better than that of budesonide inhaler plus formoterol inhaler in children with bronchial asthma, which is more convenience and has a better compliance.
