Effect of interferon adjunctive therapy on TH1/TH2 and IL-12 of patients with chronic hepatitis B
- VernacularTitle:干扰素辅助治疗对慢性乙型肝炎患者血清TH1／TH2及IL-12水平影响研究
- Author:
Sufen XIAO
;
Yongshui SHU
;
Guangrong ZHANG
- Publication Type:Journal Article
- Keywords:
interferon;
adjuvant therapy;
chronic hepatitis B;
TH1/TH2;
IL-12
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(11):83-85
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore effect of interferon adjunctive therapy on TH1/TH2 and IL-12 of patients with chronic hepatitis B. Methods 105 cases of chronic hepatitis B patients were collected.105 cases were divided into the control group and the experiment group.52 cases in the control group were treated with non antiviral therapy, 53 cases in the experiment group were treated on the base of the control group with interferon adjunctive therapy .Clinical curative effect, serum TH1/TH2 and IL-12 were compared after the treatment.Results Compared with the control group, the clinical total effective rate was higher (P<0.05); the IL-2 level in the experiment group was lower (P<0.05); the IL-4, IL-12 level in the experiment group were higher (P<0.05).Conclusion Interferon assisted therapy can improve the clinical efficiency and quality of life in patients with chronic hepatitis B, and it can be related to the decrease the level of erum IL-2, and rise the level of IL-4 and IL-12.
