Different doses of propofol infusion on serum lipid metabolism and pulmonary function in patients with cervical cancer surgery
- VernacularTitle:不同剂量异丙酚术中输注对腹腔镜宫颈癌手术患者脂质代谢及肺功能影响研究
- Author:
Shumin JI
;
Yanping SHEN
;
Wenhang ZOU
- Publication Type:Journal Article
- Keywords:
propofol;
cervical cancer;
lipid metabolism;
pulmonary function
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(11):127-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of different doses of propofol infusion on serum lipid metabolism and pulmonary function in patients with cervical cancer operation.Methods 120 patients with cervical cancer were randomly divided into A, B, C three groups, 40 cases in each group, were treated with laparoscopic cervical cancer radical operation, the 4 mg/(kg· h), 6 mg/(kg· h), 8 mg/(kg· h), and the pulmonary function and lipid profiles were detected.Results Compared with the B and C groups, the recovery time and the the awake time of the patients in B ,C group was shorter (P<0.05).The recovery time and the the awake time of the patients in A group had not significantly different.Compared with before operation, TG, TC and LDL levels were elevated, HDL decreased in theree groups after the operation(P<0.05);compared with the A and B groups, the levels of TC, LDL, TG and were higher, the level of HDL were lower (P<0.05),there were no significant differences in level of TC, HDL, TG and LDL between group A and group B;there was no significant difference between P(A-a) O2 and RI among three groups before surgery, P(A-a) O2 and RI levels were elevated in the three groups after surgery(P<0.05), compared with the A and B groups, P(A-a)O2 and RI levels in group C were lower(P<0.05), there was no significant difference in P(A-a)O2 and RI between group A and group B.Conclusion 4 mg/(kg· h)of propofol can significantly shorten the recovery time and awake time, improve the level of lipid metabolism and pulmonary function.
