Effect of nalmefene hydrochloride adjuvant therapy on serum NO, endothelin and cardiac troponin I in patients with traumatic shock
- VernacularTitle:盐酸纳美芬辅助治疗对创伤性休克患者血清NO、内皮素及肌钙蛋白I水平影响研究
- Author:
Yuanwen WANG
;
Wenlin ZHAO
;
Qing LI
- Publication Type:Journal Article
- Keywords:
nalmefene hydrochloride adjuvant therapy;
traumatic shock;
nitric oxide;
endothelin;
cardiac troponin I
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(11):149-151
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse effect of nalmefene hydrochloride adjuvant therapy on serum nitric oxide(NO), endothelin (ET) and cardiac troponin I ( cTnI) in patients with traumatic shock.Methods 48 patients who were diagnosed with traumatic shock were collected.All patients were randomly divided into experimental group and control group, 24 cases in each group.On the basis of conventional anti shock treatment, the control group were treated with naloxone, the patients in experimental group received nalmefene hydrochloride treatment, after treatment, the serum levels of NO, endothelin and cardiac troponin I were detected in all patients.Results After treatment, compared with control group, the serum level of NO was lower in experimental group(P<0.05);the serum level of ET was lower in experimental group(P<0.05);the serum level of cTnI was lower in experimental group(P<0.05).Conclusions Nalmefene hydrochloride adjuvant therapy could significantly reduce the serum levels of NO, ET and cTnI in patients with traumatic shock,control the development of the disease, prevent myocardial injury.
