Clinical analysis on juvenile dermatomyositis combined with soft-tissue calcification
10.3760/cma.j.issn.1673-4904.2015.10.009
- VernacularTitle:幼年皮肌炎合并软组织钙化临床分析
- Author:
Xiaoyun LI
;
Hengchuang TIAN
;
Wenjia GU
;
Chunyan WANG
;
Jie LAN
- Publication Type:Journal Article
- Keywords:
Dermatomyositis;
Retrospective studies;
Solt-tissue calcification
- From:
Chinese Journal of Postgraduates of Medicine
2015;38(10):733-736
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical features of juvenile dermatomyositis (JDM) combined with soft-tissue calcification. Methods Forty-seven patients with JDM combined with soft-tissue calcification (soft-tissue calcification group) were retrospectively analyzed, and they were contrasted with 89 patients with non-calcification (non-calcification group). Results The rates of Gotton signe, muscle contracture and joint dysfunction in soft-tissue calcification group were significantly higher than those in non-calcification group:87.23% (41/47) vs. 43.82% (39/89) and 68.09% (32/47) vs. 21.35% (19/89), and there were statistical differences (P<0.05). The dosage of glucocorticoid (conversion of prednisone measuring more than 1.5 mg/kg), rate of using immunodepressant, level of creatine kinase in soft-tissue calcification group were significantly lower than those in non-calcification group:17.02%(8/47) vs. 68.54%(61/89), 25.53%(12/47) vs. 88.76%(79/89), (566.45±240.41) U/L vs. (1 680.12±656.50) U/L, and there were statistical differences (P<0.05). Conclusions The patients with JDM combined with Gotton signe are more prone to soft-tissue calcification. The rate of muscle contracture and joint dysfunction in soft-tissue calcification patients is significantly higher than that in non-calcification patients. For the patients whose creatine kinase are not obviously elevated, they are more prone to soft-tissue calcification. Early active application of glucocorticoid and immunodepressant therapy can reduce or prevent the occurrence or development of late calcium deposition.
