Role of Sonic Hedgehog signal pathway in embryogenesis and neural regeneration
10.3969/j.issn.2095-4344.2015.46.026
- VernacularTitle:SonicHedgehog信号通路在胚胎发育及神经修复中的现状与进展
- Author:
Suping WANG
;
Xiaojun WU
;
Xu YAN
;
Hong ZHAO
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2015;(46):7523-7528
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Many studies have showed that Sonic Hedgehog (Shh) signal pathway regulates the proliferation and differentiation of nerve cels, axon guidance and neural regeneration after brain injury. OBJECTIVE:To summarize the role of Shh signal pathway in embryonic development and post-natal nerve repair. METHODS:A computer-based retrieval was performed by the first author in PubMed and CNKI database to search related papers published from January 1980 to July 2015 using the keywords of “Shh signal pathway, embryogenesis, neural regeneration” in English and Chinese, respectively. Articles related to Shh signal pathway in embryonic cels differentiation, tissue development, post-natal neural regeneration, axon migration and tumor formation. A total of 38 relevant literatures were retrieved. RESULTS AND CONCLUSION: Recently, Shh signal pathway has become an issue of concern because this signal pathway is closely related with neural regeneration after brain injury. Shh is widely expressed in Hedgehog (Hh) family and plays a crucial role in embryogenesis and organogenesis. Shh is wel known to contribute to the patterning of neural tube system, regulate the proliferation and migration of progenitor cels, and control axonal growth and guidance. In addition, Shh is closely related to tumor formation. Studies have shown that Shh can reduce infarct volume and improve behavior prognosis of stroke rats.
