Mesenchymal stem cells in the inflammatory immunomodulation
10.3969/j.issn.2095-4344.2015.45.026
- VernacularTitle:间充质干细胞在炎症免疫调节中的作用及应用进展
- Author:
Sheng ZHENG
;
Juan YANG
;
Yingmei TANG
- Publication Type:Journal Article
- Keywords:
Mesenchymal Stem Cel Transplantation;
Immunomodulation;
Inflammasomes;
Tissue Engineering
- From:
Chinese Journal of Tissue Engineering Research
2015;(45):7362-7368
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Studies have shown that the main functions of mesenchymal stem cels include direct participation in wound healing, growth factor secretion, promoting angiogenesis, immune regulation and inflammation, anti-oxidative stress, which can be used to treat a variety of acute and chronic diseases. OBJECTIVE:To review advances in mesenchymal stem cels in the inflammatory immunomodulation. METHODS: A computer-based search of Wanfang, CNKI and PubMed databases was performed for articles concerning advances in mesenchymal stem cels in the inflammatory immunomodulation published from January 2005 to August 2015. The search terms were “stem cels, mesenchymal stem cels, immune regulation, inflammation, immune cels, inflammatory factors, treatment” in Chinese and English, respectively. Finaly, 40 articles were included in result analysis. RESULTS AND CONCLUSION:Because of their immunomodulation and muti-directional differentiation, mesenchymal stem cels garner increasing attentions. In addition, mesenchymal stem cels can be harvested from different tissues and have goodin vitroamplification capability, which have a broad prospect in the clinical use, including tissue repair and anti-inflammation. As the most promising cels used clinicaly, mesenchymal stem cels show their superiority in the treatment of many diseases, especialy in inflammations induced by immune modulation imbalance. We believe that mesenchymal stem cels wil play an important role in the future cel biotherapy.
