SPECT/CT imaging characteristic of osteolytic lesions with increased bone metabolism and its corre-lation with CT manifestation
10.3760/cma.j.issn.2095-2848.2015.06.011
- VernacularTitle:溶骨性骨代谢增高病灶的SPECT／CT骨显像特点及与CT表现的相关性
- Author:
Shu WANG
;
Yaming LI
;
Na LI
;
Bulin DU
- Publication Type:Journal Article
- Keywords:
Neoplasm metastasis;
Skeleton;
Radionuclide imaging;
Tomography,emission-computed,single-photon;
Tomography,X-ray computed;
MDP
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2015;(6):466-469
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristic of SPECT/CT imaging of osteolytic lesions with increased bone metabolism and its correlation with CT manifestation. Methods Twenty?one cancer patients with bone metastases underwent 99 Tcm?MDP SPECT/CT imaging ( 13 males, 8 females; age: ( 60. 52 ± 6?85) years) were retrospectively studied. The imaging characteristic of the lesion with high uptake of 99Tcm?MDP was observed and the correlation between the lesion/background ( L/B ) ratio and CT manifestation were analyzed. One?way analysis of variance, two?sample t test and linear correlation analysis were used. Results A total of 111 lesions were found in 21 patients by 99 Tcm?MDP whole?body bone scan, and 125 le?sions were found by SPECT/CT imaging, including 111 lesions with increased bone metabolism and abnor?mal CT manifestation and 14 osteolytic lesions with decreased bone metabolism. In 111 lesions with in?creased bone metabolism, there were 23(20.72%) osteolytic lesions, 54 (48.65%) osteoblastic lesions and 34 (30.63%) mixed lesions. The L/B ratio of osteolytic lesions with increased bone metabolism (11.82± 6?61) was lower than that of osteoblastic lesions (20.03±13.24) and that of mixed lesions (25.42±19.51;F=6.00, P<0?05) . The CT value of osteolytic lesions with increased bone metabolism was higher than that of osteolytic lesions with decreased bone metabolism :(167.53±79.21) HU vs (88.63±49.16) HU; t=3?345, P<0.05. The L/B ratio of lesions with increased bone metabolism was positively correlated to CT val?ue(r=0.404, P<0?05). Conclusions A part of lesions with increased bone metabolism on SPECT/CT im?ages are osteolytic lesions. The L/B ratio of them is positively correlated to CT value. SPECT/CT imaging can reduce missed diagnosis and misdiagnosis.
